Adnan Qadir, Irfan Younis, Brig Shahid Raza Khalid, Zamir Butt, Shahid Sarwar.
Helicobacter pylori infection; comparison of stool antigen test and histology of endoscopic biopsy for diagnosis.
Professional Med J Jan ;23(10):1243-6.

Objectives: To determine diagnostic accuracy of H.pylori Stool Antigen test for diagnosing Helicobactor pylori infection, keeping histopathology as gold standard. Study design: Cross sectional Validation Study. Place and duration: Study was conducted in department of Gastroenterology Military Hospital, Rawalpindi for six months from 1st November 2014 to 30th April, 2015. Patients and methods: Serial patients presenting with dyspepsia fulfilling the inclusion criteria were entered in study program. Endoscopy was performed to take antral biopsies for histopathology and stool was taken to test H.pylori antigen. SPSS version 16.0 was used to analyze the data. Results: Eighty (72.2%) out of 110 patients were male, the mean age and standard deviation was 33 ±16yrs. Three patients left study just before starting endoscopy. Eighty (74.76%) cases out of 107 patients were both positive for histology and HpSA test. Stool for H.pylori test was positive in 82 (76.63%) while histopathological diagnosis was made in 83(77.57%) patients. The sensitivity and specificity were 96.3% and 91.66% while positive and negative predictive values of the stool H.pylori test were 97.56%, and 88.0% respectively. Overall the diagnostic accuracy of stool H.pylori test was 94.4% for diagnosis of H. pylori infection. Conclusion: Stool for H.pylori Antigen can be used as alternative to histopathology due to its non-invasive nature, patient’s preference and ease of repetition.

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