Noor Khan Lakhnana, Ijaz Ahmed, Sameeh J Khan.
IgA nephropathy in northern Pakistan.
J Pak Inst Med Sci Jan ;6(1,2):356-62.

A light and immunofluorescence microscopy study was performed on 238 patients on whom percutaneous renal biopsies were obtained. On light microscopy the glomerular lesions were predominantly focal WHO Class III and diffuse mesangial proliferative glomerulonephritis Class IV. The mesangial deposits showed high association with IgM deposits and presence of early complement components, indicative of both classical and alternative pathways of C3 activation in our patients. The main presentation was with nephrotic syndrome, proteinuria, and microhaematuria in our patients. This study shows the existence of IgA nephropathy in Pakistan but not as frequent as reported in papers from other countries. This is a review article.

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