Shafat Khatoon, Aijaz Ahmed, Nighat Jabeen, Erum Rehman.
Hypothyroidism; as a cause of dyslipidemia in young predisposes to increased risk of cardiovascular disease.
Professional Med J Jan ;24(1):36-41.

Cardiovascular diseases (CVDs) are the number one cause of death globally: more people die annually from CVDs than from any other cause. An estimated 17.5 million people died from CVDs in 2012, representing 31% of all global deaths. Although CVDs are uncommon entity in young patients, it constitutes significant health problem due to its dyslipidemia cases and devastating effects on active life style of young patients, it is therefore important to identify diseases in young that are associated with or a cause of dyslipidemia1 . Hypothyroidism is an important cause of dyslipidemia in young that can significantly increase the risk of CVDs2 . Objectives: This study is designed “to determine frequency of dyslipidemia in young hypothyroid patients”. Place and duration of Study: Study conducted at Medical OPD JPMC, Karachi (outpatient) in six months duration from 25th May 2009 to 24th November 2009. Patients and Methods: Study is performed on 100 newly diagnosed cases of primary hypothyroidism between ages 25 to 55 years, non-smokers, having no previous history of Ischemic Heart Disease (IHD) or family history of premature CVD, diabetes mellitus (DM), hepatic or renal disease, not on drugs which could alter serum lipids. Selected case undergone 14 hours fasting lipid profile check. Results: Out of 100 hypothyroid cases, 91% had dyslipidemia which was directly proportional to severity of hypothyroidism. Out of 100 hypothyroid cases, 95 (95%) were of young age group i-e from 25-49 years, and all of them were dyslipidemic, while 05 (5%) hypothyroid patients were of age group more than 50 years and none of them had dyslipidemia. (0.00%) and this distribution of dyslipidemic in young hypothyroid patients is statistically significant (p value 0.031) Conclusion: Hypothyroidism is associated with high frequency of dyslipidemia in young patients which significantly predisposes them to risks of CVDs.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com