Tariq Parvez.
Germ Cell tumors of Testis: An update in Chemotherapy treatment.
J Coll Physicians Surg Pak Jan ;12(8):500-5.

Prior to the use of cisplatin, durable complete remission of metastatic testicular cancer were rare. In 1977, a chemotherapy treatment program including cisplatin, vinblastine, and bleomycin (PVB) led to high response rates and acceptable toxicity in patients with disseminated testicular cancer. After that, bleomycin, etoposide, and cisplatin (BEP) chemotherapy regimen was established as a standard therapy for good- and poor-risk disease and further, ifosfamide-based regimens or high-dose chemotherapy with stem cell rescue as the salvage therapy. The results of these prospective, randomized clinical trials that have markedly improved the outlook of patients with this type of cancer have been reviewed in this article. While the present state-of-the-art treatment for metastatic testicular cancer is promising, approximately one-third of patients with `poor-risk` disease will not achieve a remission. Trials of new agents and approaches are needed to increase the patient survival. This is a review article.

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