Faizania Shabbir, Mazhar Hussain, Tausif Ahmed Rajput, Alamgir Khan.
Effect of obesity and statin; newly emerging cardiovascular risk factor; mean platelet volume in male and female sprague dawley rats.
Professional Med J Jan ;24(2):216-20.

Objectives: To observe the effect of obesity and subsequent atorvastatin administration on MPV in high fat diet induced obese male and female Sprague Dawley rats. Study Design: Randomized control trial (RCT). Setting: Department of Physiology, Army Medical College, Rawalpindi. Animal procurement and blood sampling was done at National Institute of Health (NIH), Islamabad and biochemical assays were performed at Centre for Research in Experimental and Applied Medicine (CREAM), Army Medical College, Rawalpindi. Period: The study was completed in 12 months. Material and Methods: Ninety healthy Sprague Dawley (male and female) rats were purchased and divided randomly into three equal groups. Rats in normal control group (Group I) were given normal chow diet for three weeks. Rats in obese control group (Group II) were given high fat diet for three weeks. Rats in obese treated group (Group III) were administered atorvastatin for three weeks in a dose of 10 mg/kg/day orally by gavage method after obesity induction. Terminal sampling was done at the end of the study by intra-cardiac puncture. MPV is a part of blood complete picture that was analysed by KX 21 Sysmex Hematology Analyzer. Results: High fat diet induced obesity resulted in a significant (p < 0.05) increase in MPV. The MPV was significantly (p < 0.05) decreased after atorvastatin administration. The result was comparable for both genders. Conclusions: Obesity increases MPV and hence the risk of adverse cardiovascular outcome. Atorvastatin apart from its known lipid lowering effect, decreases MPV and can play a beneficial role in decreasing cardiovascular morbidity and mortality.

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