Najla Shore, Rukhshan Khurshid, Farida Munawar.
Serum Leptin Level In Adolescent Girls With Polycystic Ovary Syndrome: Correlation With Anthropometric And Endocrine Parameters.
Pak J Physiol Jan ;13(1):3-6.

Background: Polycystic Ovary Syndrome (PCOS) is linked with hyperinsulinemia and insulin resistance, characteristics that are linked to the level of leptin and leptin receptors. This study was planned to estimate serum leptin levels in adolescent girls with PCOS and its relation with endocrine and anthropometric parameters. Methods: Fifty (50) girls with PCOS, aged 16–20 years, and 60 agematched normal subjects were included in the study. Study duration was from Jun 2014 to Dec 2016. Patients were taken from Sir Ganga Ram Hospital, Lahore. Normal subjects (controls) were students of Fatima Jinnah Medical University, Lahore. Serum levels of Fasting blood sugar, leptin, testosterone, and serum insulin were estimated. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was used to calculate insulin resistance. Body mass index (BMI) was calculated using the standard formula. Results: Mean age of adolescent girls with PCOS was 19±2.8 years. BMI of PCOS patients was increased non-significantly compared to normal subjects. Fasting blood sugar and serum testosterone level was non-significantly decreased in PCOS patients compared to normal subjects. Level of serum insulin was significantly increased in patients compared to normal subjects. On the other hand, serum leptin level was increased in patients as compared to normal subjects. A weak correlation between leptin hormone, serum insulin and insulin resistance was observed. Significant positive correlation was observed between BMI of PCOS women and their leptin hormone. Conclusion: In adolescent girls, increased leptin level showed a significant correlation with BMI, whereas its correlation with endocrine parameter was weak.

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