Qudsia Tehseen, Attia Bari, Iqbal Bano, Uzma Jabeen, Ahsan Waheed Rathore.
Frequency of Impaired Glucose Tolerance in Beta Thalassemia Major Patients.
Pak Paed J Jan ;41(3):131-6.

Objective: To determine the frequency of impaired glucose tolerance in beta-thalassemia major patients. Study design: A descriptive cross sectional study. Place and Duration of Study: The Department of Pediatric Medicine, thalassemia clinic of The Children’s Hospital Lahore from December 2014 to June 2015 Methodology: A total of 260 cases of beta thalassemia major, 5-15 years of either gender were included. Patients with other hemoglobinopathies and known case of diabetes mellitus were excluded. In every patient, Oral glucose tolerance test (GTT) was done after an overnight fast. For GTT, two ml blood was taken from fasting patients and 1.75 g/kg glucose solution was given orally to them and 2 hours later blood sampling was repeated. Impaired glucose tolerance (IGT) was labeled as fasting plasma glucose ≥112mg/dl to ≤126mg/dl and 2 hours post-prandial plasma glucose ≥140mg/dl but <200mg/dl. Results: Out of the 260 patients, 153 (58.85%) were male and 107 (41.15%) were females with male to female ratio of 1.4:1. Majority of the children [160 (61.5%)] were in 5-10 years of age with mean age of 10.80 ± 3.44 years. Mean duration of disease was 8.23 ± 3.15 years. Mean blood transfusions/year were 13.68 ± 5.49 transfusions/year. IGT was found in 63 (24.23%) cases. Family history of diabetes and >12 transfusions/year were significantly associated with IGT (p-value< 0.001 and 0.01 respectively). Conclusion: In β-thalassemia major patients the impaired glucose tolerance was 24.23% and was significantly associated with diabetes in the family and increased blood transfusion requirement/year.

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