Rabbiah Manzoor Malik, Sajida Bano, Rafique Ahmed.
Correlation of Advanced Glycation End Products (AGEs) with the level of Alanine Amino Transferase (ALT) and Aspartate Amino Transferase (AST) Enzymes in Chronic Diabetic Patients.
Med Forum Jan ;2(12):57-60.

Objective: Objective of this study is to find Correlation of Advanced Glycation End products (AGEs) with the level of Alanine amino transferase (ALT) and Aspartate amino transferase (AST) enzymes in chronic diabetic patients. Study Design: case Control Study Place and Duration of Study:This study was conducted at the laboratory of Department of Biochemistry, University of Agriculture, Faisalabad from December 2009 to May 2010. For this study blood samples were collected from Pakistan Institute of Medical Sciences, Islamabad. Materials and Methods: In the present study, the level of protein glycation in human serum samples of healthy older and young control subjects (n = 20), and diabetic patients (n = 45), were investigated. The patients were selected on clinical grounds from Pakistan Institute of Medical Sciences Results: Serum AGEs were found to be significantly (P < 0.001) increased in diabetic patients as compared to healthy older subjects and control subjects. However, no significant difference was found in the level of AST and ALT in diabetic patients and control group. The AGEs distribution in the these groups reveals the hypothesis that the advanced glycation process might play a role in the development of liver diseases, but in this study no correlation has been found in level of glycation and such liver damage which could result in decreased or increased formation of AST and ALT. Conclusion: No study have been found regarding level of glycation and level of AST and ALT in diabetic patients. From this study we conclude that no correlation is present in level of glycation and level of AST and ALT in blood in diabetes. Since, there is no effect of AGE formation on production of ALT and AST in liver.

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