Mehwish Nisar, Muhammad Waqas Nisar Ahmed, Beenish Nisar Ahmed, Arshi Imran, Sana Nisar Ahmed.
Stress and the Onset of Type 2 Diabetes.
Ann Jinnah Sindh Med Uni Jan ;2(2):48-52.

Introduction: The positive response of a correlation between psychological stress and impaired diabetes control is very old. Thomas Willis commented on the ability of "nervous liquors" to affect diabetes in the 17th Century, and William Osler in the 19th Century. Now it is well accepted that psychological reaction to stressors, leads to various endocrine abnormalities that antagonize the action of insulin. But, until recently, there has been very little research evidences are available to confirm that there is a connection between high stress state and the onset of diabetes. In this study we are trying to evaluate the basic association, of the presence of high level of stress before the onset of type 2 diabetes. Materials & Methods: A retrospective cross-sectional study was conducted on 339 patients with Type II Diabetes, within one year of onset of the disease, presenting at National Institute of Diabetes and Endocrinology, Dow University of Health Sciences, Karachi between December 1, 2015 to May 31, 2016. Data was collected using a validated questionnaire, Holmes Rahe Life Stress inventory containing 51 stressful events. All the data was sorted and analyzed on Statistical Package Social Sciences (SPSS) Version 22. Results: Out of 339 patients, 68.73% (n=233) individuals reported with high levels of stress. Males (61.8%, n=144/233) were found to be more frequently associated to high stress levels as compared to females (38.2%, n=89/233). Majority of the individuals belonged to the age group 40-49 years (51.5%, n=120/233), while a significant fraction had family history of diabetes (n=188/233, 80.6%). Conclusion: This study reported that a significant number of our patients were in a state of high stress before they had diabetes .This shows a positive correlation between the onset of diabetes and the level of stress. It can be concluded that stress management will play a very important role in decreasing the incidence of diabetes. Because of stress management, people can also delay the onset of diabetes, which is present in their genes. Key words: Onset of type 2 diabetes, stress.

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