Salman Shafique, Syed Mahmood Haider, Zahid Ali.
Histological Patterns and Clinical Presentation of Oral Squamous Cell Carcinoma.
J Pak Dent Assoc Jan ;19(3):171-6.

OBJECTIVE: The objective of our study was to identify the different histological patterns of Oral Squamous cell carcinoma (OSCC) in relevance to demographic variables and to evaluate histological patterns according to various clinical presentations at the joint department of Oral Surgery, Karachi Medical and Dental College and Abbasi Shaheed Hospital Karachi. METHODOLOGY: This descriptive study was conducted from December 2005 to November 2006 at Oral Surgery Department of Karachi Medical & Dental College and Abbasi Shaheed Hospital Karachi. A total of 60 cases presenting with OSCC were included in this study. Their demographic details, habit profile, clinical information of lesion were recorded on a proforma. All the patients underwent biopsy and their histological information was also noted on the same proforma. RESULT: This study included 60 patients of OSCC. Fifty eight percent of patients were from age group between 41-60 years. Approximately 63.3 % males and 36.7 % females were affected and male to female ratio was 1.7: 1. Approximately 48.3 % of lesions involved alveolus. Nearly 86.7 % of patients were indulged in habits of tobacco chewing. Clinical appearance of lesion showed that 66.7% of lesions were ulcerative type and histologically 48.3% were well-differentiated OSCC. CONCLUSION: Majority of patients were indulged in habit of tobacco chewing. Ulcerative type was the dominant clinical presentation whereas histologically well-differentiated OSCC was the most common presentation. Infiltration was a consistent finding in all cases.

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