Sana Naz, Faisal Irshad, Hina Mawani.
CCI4 Induces Liver Injury; Aqueous Extract Of Ginkgo Biloba (GKBE) Ameliorates Cytoplasmic And Mitochondrial Enzymes.
Professional Med J Jan ;24(5):739-44.

Objectives: Evaluate the mitigating effect of aqueous extract of Ginkgo biloba (GkbE) on liver enzymes and histology in carbon tetrachloride (CCl4 ) induced liver injury in albino rat. Study design: Experimental study. Setting and Duration: Animal house, Bhitai Dental and Medical College Mirpurkhas and Agriculture University Tando Jam from Animal house from May 2015 - August 2016. Subjects and Methods: Sixty rats were equally divided into 3 groups Group 1- Controls (0.9% isotonic saline), Group 2- (CCl4 CCl4 1.0mg/ kg intraperitoneal) and Group 3- (CCl4 + GkbE). Blood samples were collected at end of experiment from tail veins. Liver was obtained after rat sacrifice by cervical dislocation. Tissue was fixed in formaldehyde and embedded in paraffin. Microscopy of 3μ tissue sections was performed after H & E staining. Statistix 10.0 (USA) software was used for data analysis at 95% confidence interval. Results: Four weeks GkbE administration in CCl4 rat showed significant amelioration of liver enzymes and improved liver histology (p=0.0001). In GkbE treated rats, the histological changes of degeneration, fatty change, inflammatory cell infiltration, sinusoid congestion and necrosis was minimal (p=0.0001). GkbE was proved of mitigating the hepatocellular injury inflicted by carbon tetrachloride. Conclusion: GkbE mitigates the carbon tetrachloride induced liver injury in rat model. GkbE may be used in drug and chemical induced liver injury.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com