Muhammad Sheraz Javed, Safdar Hassan Javed.
Prostatic Hyperplasia; Comparison Between Tamsulosin And Terazosin For Efficacy In Medical Management Of Lower Urinary Tract Symptoms Secondary To Prostatic Hyperplasia.
Professional Med J Jan ;24(10):1560-5.

Lower Urinary Tract Symptoms. Alpha-1 adrenoceptor antagonists are most frequently prescribed medical management for LUTS and among these tamsulosin and terazosin are the most common. Objectives: To access comparison of efficacy of tamsulosin and terazosin for management of LUTS due to prostatic hyperplasia in terms of International Prostate Symptom Score (IPSS). Place and duration: Study being conducted at Department of Urology and Kidney Transplantation, Allied Hospital, Faisalabad for period of 24 months from 01-07-2014 to 30-06-2016. Methodology: 659 male patients enrolled in study and randomly assigned to Group A (Patients being administered with tamsulosin) and Group B (Patients being administered with terazosin) and improvement in IPSS monitored over period of two weeks. Results: 659 patients enrolled with mean age+sd as 61.9+10.2 years. Group A includes 330 patients while Group B include 329 patients. Among Group A, 250 patients showed significant improvement in IPSS while in Group B, 215 patients showed significant response to medical management in terms of IPSS and both groups showed statistically comparative response. Statistical response of management also determined in terms of variables of IPSS severity, prostatic size and age of patient and found that efficacy of the two groups were statistically comparable for patients with mild IPSS while in patients with moderate IPSS has response to treatment with tamsulosin but no statistical association of efficacy for treatment with terazosin. No statistical response was found for improvement in symptoms in cases with severe IPSS in either groups. When response monitored in terms of prostate size in both groups, it was found that both groups have statistical response when prostate size is less than 35 grams, between 35-55 grams but in case when prostate size was more than 55 grams, no statistical response was found with group B patients. When response was measured in terms of variable of age, results were consistent with the fact that statistically significant response of efficacy was found in either groups for age group 45-55 years and 56-65 years but no statistical response was found for Group B when considered for age group more than 65 years. Conclusion: Based on results it is concluded that both tamsulosin and terazosin has got comparative results in overall response. However, tamsulosin has superiority in treatment when IPSS is moderate, prostate size is more than 55 grams and age of patient is more than 65 years.

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