Aurangzeb Afzal, Sana Fatima, Aizaz Mand Ahmed.
Methanol Poisoning; Challenging Diagnosis And Management Without Fomepizole And Ethanol.
Professional Med J Jan ;24(3):490-4.

Acute methanol poisoning produces severe metabolic acidosis, increased anion and osmolal gaps. These metabolic disturbances are due to accumulation of formic acid with has serious neurological sequelae. If renal functions starts deteriorating that is associated with increased mortality. Early diagnosis and treatment can reduce morbidity and mortality. Treatment include infusion of sodium bicarbonate and administration of ethanol orally or parentally to inhibit the production of formic acid from methanol. Hemodialysis is helpful in removal of methanol and its breakdown products from circulation and also in correcting acidosis. We report the case of a boy admitted to the emergency room with a history of acute illness, characterized by nausea, vomiting, blurred vision, and shortness of breath. Arterial blood gases showed severe metabolic acidosis with high anion gap. He had ingested large quantity of alcohol containing methanol. The patient was managed with hemodialysis and strong intravenous hydration. He improved well and made a full recovery.

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