Shagufta Memon, Navaid Kazi, Amin Fahim, Ghulam Shah Nizamani, Anila Qureshi.
CHRONIC KIDNEY DISEASE; The association of platelet count with estimated glomerular filtration rate in known cases.
Professional Med J Jan ;23(07):784-8.

Objectives: This study aimed to determine the platelet count in diagnosed chronic renal failure patients and to find out the association of platelet count with glomerular filtration rate. Study Design: Case control study. Place of study: Diagnostic and research laboratory Liaquat University Hospital Hyderabad and Nephrology Unit, Isra University Hospital Hyderabad. Duration of study: January 2015 to July 2015. Materials and methods: Total of one hundred and twenty subjects (n=120) were divided into two groups. The healthy controls (n=60) were included in group-I whereas patients with chronic renal failure (n=60) were kept in group-II. 5 ml of blood was drawn and sent to laboratory for estimation of serum platelet count, blood urea nitrogen and serum creatinine levels. Results: The present study showed highly significant difference with marked decrease in the platelet counts seen in the CRF patients with 223.9±89.1 million/µL in comparison to the 347.60±55.9 million/µl platelets in control individuals. Also the results of BUN in CRF patients showed highly significant differences with 27.67±7.68 mg/dl when compared to controls having BUN 8.95±1.02 mg/dl. The comparison between GFR with mean platelet count showed negative correlation (r = -0.27) in CRF patients. Conclusion: The present study shows weak negative correlation of platelet count with GFR.

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