Palwasha Abbasi, Abdul Rahim Memon, Sadia Tabassum Abbasi, Sadia Kazi, Shomail Siddiqui.
HYPERGLYCEMIA; Catharanthus roseus & nigella sativa ameliorate in alloxan induced diabetic rats.
Professional Med J Jan ;22(8):1048-52.

To investigate blood glucose regulaitng effects of Catharanthus Roseus (C.roseus) and Nigella sativa (N.sativa) in alloxan induced diabetic rats. Study Design: Experimental study. Place and Duration: Animal house Isra University Hyderabad. From April to Novermber 2013. Methodology: 50 male rats were housed at normal température, 12 hour dark - light cycle with free access to chow and water. A single intraperitoneal bolus of alloxan (120 mg/kg) was given to induce diabetes mellitus. Glimepiride, C. roseus and N. Sativa were administered at doses of 0.1 mg/kg, 125 mg/kg and 50 g/kg respectively. Data was analyzed on SPSS version 21.0. Significant P - value was defined at ≤ 0.05. Results: C.roseus ad N.sativa showed blood glucose lowering potential but the effect was less when compared to glimepiride (P = 0.001). However, C. roseus was more effective compared to N.sativa (P = 0.001) in reducing blood glucose. Findings suggest that both C. roseus and N. sativa possess glucose regulating potential. Conclusion: It is concluded that the C. roseus and N. sativa exert blood glucose regulating effects in alloxan induced diabetic rat model.

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