Objective: To find out histologically proven cases of acute appendicitis, cases of normal appendices and to see involvement of this organ by diseases other than acute inflammation. Design: A descriptive study. Place and Duration of Study: Armed Forces Institute of Pathology and Army Medical College, Rawalpindi from September 1990 to May 2002. Materials and Methods: A total of 2774 surgically resected appendicectomy specimens of patients of both sexes with different socioeconomic class were received in 10% formal-saline. The clinical informations were collected from clinicians, attendants of patients and clinical notes written on the laboratory request forms. The gross examination and representative sections were taken according to method described in Ackerman`s Surgical Pathology Book. These sections were stained with Haematoxylin and Eosin and special stains as and when required. Results: The age of patients ranged from 2 to 73 years and males were two times more affected than females. Microscopically, 66.54% patients showed early acute/acute suppurative appendicitis and 32.66% patients did not reveal any pathology. Chronic granulomatous inflammation was found in 0.40% cases, carcinoid in 0.22% patients and cases of mucocele were also noted in 0.18% patients. Conclusion: Proportion of negative appendicectomy rate was 32.66%. Hence other diagnostic procedures for appendicitis should be evaluated to decrease this negative rate.
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