Israr-ud Din, Zakirullah, Asghar Ullah, Inayatullah Khan, Muhammad Hafeez.
Frequency of Malignancy in Solitary Thyroid Nodule.
Pak J Otolaryngol Jan ;29(1):16-8.

OBJECTIVE: To determine the frequency of malignancy in discrete solitary thyroid nodule in 139 patients in a tertiary care hospital of Peshawar during one year period. SUBJECTS & METHODS: This was a cross sectional study made during August 2010 to August 2011 involving 139 patients with solitary thyroid nodule. The patient’s demographic data age and gender were recorded. The diagnosis of solitary thyroid nodule was based in clinical examination including palpation and ultrasound was done to confirm the solitary nature of the thyroid nodule patients having multiple nodular goiter and diffuse thyroid swelling was excluded. Subsequently thyroid nodule was removed surgically and examined histopathologically to confirm the presence of malignancy. The data were recorded in a pre-scheduled proforma. RESULTS: Among the 139 patients, male were (N:35) and female (N:104) with a male to female ratio of 1:3. Patients had their age ranging from 17 to 75 years (X= 43.99 + 13.9 SD). Malignancy in the solitary thyroid nodule was found in 22(15.8%) as compared to 117(84.1%) as non malignant. Malignancy was more common in female. Malignancy was more common 50% in the age range from 31-45 years. Papillary carcinoma was more common followed by follicular carcinoma. CONCLUSION: Considering the large number of patients with solitary thyroid nodule having malignancy, it is suggested to screen patients as well as to create awareness for surgery and medical consultation among patients.

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