Muhammad Abid Shah, Shams Suleman, Saadatullah.
Role of itopride in minimizing post prandial glucose excursion in type 2 diabetic patients.
J Med Sci Jan ;22(2):73-5.

Objective: To determine the effect of itopride (Prokinetic) drug on Post Prandial Glycemia in type 2 DM. Material and Methods: This study was conducted in Department of Medicine and Department of Pharmacology, Khyber Teaching Hospital, Peshawar from January 2012 to December 2012. Total of 100 patients were enrolled in the study and categorized into two treatment groups. Each group contain 50 patients. 1st group (Control group) was given oral anti-diabetic agents and Placebo. 2nd Group (Treatment Group) was given oral anti-diabetic agents along with itopride. Fasting and two hours Post Prandial blood sugar was done. Difference between fasting and 2 hours postmeal glycemic levels were found out and then compared in the two groups. Results: Mean fasting and post load glucose for Group 1 patient was 155.24 mg/dl and 2 hour post load glucose was 331.80 mg/dl. Group II mean fasting blood sugar was 159.88 mg/dl and mean 2 hours Post Prandial blood sugar was 222.40 mg/dl. Mean difference in fasting and 2 hours post prandial blood sugar was 176.56 mg/dl and 62.52 mg/ dlrespectively in Group I and II. Conclusion: This study showed significant decrease in fasting and post prandial blood sugar level in patient taking itopride as compared to control group

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