Muhammad Roshan Sheikh, Mahmood Saeed, Fouzia Farhat, Siraj Ud Daulah.
Lens Epithelium in Senile Nuclear and Cortical Cataract.
J Coll Physicians Surg Pak Jan ;12(11):670-2.

Objective: To study the epithelial changes in cortical and nuclear senile cataract and its relation with lens thickness. Design: A prospective study. Place and Duration: Jinnah Postgraduate Medical Center, Karachi. Three years study from 1991-1994. Subjects and Methods: With the help of a scan anteroposterior diminution (thickness) of lens was recorded in 51 selected cases of senile, cortical and nuclear cataract. Lenses were removed by intracapsular cataract extraction and processed to histologically examine the epithelial changes of the staining with hematoxylin and eosin. Results: We found a significant decrease (P<0.05) in thickness of cataract lenses. This decrease was more marked in cortical cataract (P<0.001) when compared with the nuclear one. Lens epithelial cell density was found to be 3402 + 209/mm2 in cataract patients. This cell density was found to be more in nuclear cataract (more than 4000/mm3) when compared with the cortical ones (less than 3000/mm2). Moreover, no mitotic figure was observed in cortical cataract while only few were noticed in nuclear cataract. Conclusion: Decrease in cataractous lens thickness is directly proportional to inhibition of mitosis in the equatorial lens epithelium. This is more marked in cortical than in the nuclear cataract.

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