Sadaf Ibrahim, Snh Naqvi, Rehana Perveen, Hina Abrar, Zuneera Akram.
Antidiabetic Effect of Guaiacum Officinale; on Exocrine Function and Histopathology of Pancrease in Streptozotocin Induced Diabetic Rats.
Professional Med J Jan ;25(4):620-6.

Introduction: Diabetes is the most genetically transmitted disease all over the world. It badly affects the vital organs and manifest the reduction of pancreatic amylase and lipase. Objectives: This study has been designed to investigate the role of Guaiacum officinale extract in controlling of diabetes in streptozotocin (STZ) induced type 2 diabetes male albino (Wistar) rats. Study Design: Experimental. Setting: Baqai Medical University. Period: January 2017- June 2017. Method: Bark extract of Guaiacum officinale (500mg/kg) was administered to STZ induced rat. Glibenclamide (GLB) was used as standard drug. The approach of the study was to observe the effect of Guaiacum officinale on pancreatic amylase and lipase and its tissue architecture by histopathology. Rats were divided in four groups i-e control, STZ treated, STZ + GLB treated and STZ +extract treated group. Results: Guaiacum officinale significantly improve the level of pancreatic amylase and lipase as compared to the STZ induced group. Similarly the pancreatic architecture was significantly affected by STZ alone. These changes were considerably reversed by Guaiacum officinale and GLB. Conclusion: It was concluded that Guaiacum officinale herb useful to cure the diabetes and it is effective in protecting pancreas from diabetes induced damages.

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