Faiza Irshad, Rabia Sajjad Toor, Madiha Hussain.
Diabetic Nephropathy; Effects of ginger Extract on Serum Creatinine and Paired Kidney Weight in Alloxan Induced Diabetic Nephropathy of Albino Rats.
Professional Med J Jan ;25(7):1117-23.

Background: Zingiber Officinale Roscoe (Zingiberaceae family) is known as Ginger. It is famous for its antioxidant properties. Objectives: To evaluate the effects of Ginger aqueous extract on the serum creatinine and paired kidney weight in Alloxan induced diabetic nephropathy of albino rats. Study Design: Experimental study. Period: 06 months 01-01-2013 to 30 June 2013. Setting: Anatomy Department, Sheikh Zayed, PGMI Lahore. Materials and Methods: Diabetes mellitus was induced with Alloxan intraperitoneally (150 mg/ kg body weight) in Experimental groups B & C. Then the rats of experimental group C received 200mg/kg body weight of ginger aqueous extract by gavage daily for five weeks starting from 8th day after Alloxan injection. Results: Serum creatinine levels increased more in experimental group B as compared to experimental group C. Group wise comparison of creatinine level revealed that the difference among control (A group) and experimental (B & C Groups) was significant having p-value <0.001. We observed that Paired kidney weight in experimental group B increased as compared to control group A. Less increase in the paired kidney weight was observed in experimental group C as compared to experimental group B. The difference of mean paired kidney weight among three groups was significant having p-value <0.001. Conclusion: The results of the present study indicated that the co-treatment of Ginger aqueous extract prevented alloxan induced diabetic nephropathy in albino rats. The aqueous extract of Ginger showed amazing results on paired kidney weight.

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