Aisha Memon, Hassan Shahid, Salman Shafique.
Oral Submucous Fibrosis; Comparison of Efficacy Between Clobetasoland Triamcinolone Appliation in Oral Submucous Fibrosis patients with Burning Sensation.
Professional Med J Jan ;25(7):1005-12.

Objectives: To compare the efficacy of topical Triamcinolone 0.1% with Clobetasol 0.05% in the known cases of Oral Submucous Fibrosis presenting with burning sensations. Study Design: Cross sectional hospital based study. Setting: Department of Oral & Maxillofacial Surgery, Isra Dental College, Isra University Hospital, Hyderabad. Period: Six months. Materials and Methods: A sample of 50 patients was selected through nonprobability purposive sampling according to inclusion and exclusion criteria. 50 patients with Oral Submucous Fibrosis were divided into two groups, Group A and Group B, each having 25 patients. The pain was measured by the visual analog scale on the scale of 1-10. Patients were divided into Groups ?A? (Triamcinolone 0.1%) and ?B? (Clobetasol 0.05%). Patients were advised to use the gel twice a day for 3 weeks on the affected mucosal surfaces and were also advised to avoid swallowing for some minutes and not to drink or eat for at least 1 hour after the application of drug. Patients were recalled for follow up to record any improvements in burning sensations after the application of the drug. Results: It was seen that both topical drugs were beneficial in controlling the burning pain in Oral Submucous Fibrosis in the 3 weeks duration, however Clobetasol was better than Triamcinolone, as measured by more rapid control of pain by week 1. Conclusion: It is concluded that the efficacy of both topical oral drugs were useful in diminishing pain and decreasing the burning sensations. However, Clobetasol has to some extent better effectiveness in reducing the burning sensation in patients suffering with Oral Submucous Fibrosis.

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