Afshan Batool, Sanha Sarwar, Majida Zafar, Ishtiaq Anwar.
Efficacy of Tranexamic acid in treatment of heavy menstrual bleeding.
Pak J Surg Jan ;34(3):255-8.

Objective: To determine efficacy of tranexamic acid in heavy menstrual bleedings Study design: Randomized controlled trial Place & duration of study: Study was conducted at Department of Obstetrics and Gynecology, Pakistan Institute of Medical Sciences (PIMS), Islamabad. Study duration was six months (14th June 2016 to 13th December 2016) Material and methods: A sample size of 80 patients was calculated with 1:1 ratio randomization. Simple random sampling was used for recruitment of participants. Patients were randomly divided into two groups; Group A, oral dosage of tranexamic acid 3.9-4 g/day for 4-5 days starting from the first day of the menstrual cycle and Group B (Placebo), folic acid supplementation dose 400?g. patients were followed for 5 days. Efficacy of treatment was measured through mean blood loss (using pre-weighted pads). Chi- square test was applied for observing association between different variables. Results:Total 80 patients were included with 40 patients in each group. Mean age of patients in Group A (Tranexamic acid) was 25.9±0.7 SD while mean age of patients in Group B (Placebo) was 23.6±0.6 SD. Group A (Tranexamic acid) had <80 ml blood loss in 83% patients while Group B (Placebo) had <80ml blood loss in 30% patients (P=0.000). A significant association was found between mean blood loss in both group & age (p=0.001), hypertension (p=0.00 ), Diabetes mellitus (p=0.00). Conclusion: Tranexamic acid is an eff ective medical therapy for treatment of heavy menstrual bleeding. It is helpful in significant reduction of blood loss and could potentially improve women\'s quality of life.

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