Farshid Saadat, Kamiar Zomorodian, Mohammad Pezeshki, Reza Khorramizadeh.
The potential role of nonsteroidal anti-inflammatory drugs (NSAIDS) in chemopreventation of cancer.
Pak J Med Sci Jan ;19(1):13-8.

Objective: To find out the probable effects of Nonsteroidal anti-inflammatory drugs (NSAIDs) in the preventation and treatment of cancer. Design: The influence of NSAIDs on Fibrosarcoma cell line was investigated by using an in vitro cytotoxicity assay, Terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay and gelatin zymography. Setting: Department of Pathobiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences. Results: Cytotoxicity analysis of Diclofenac revealed much higher cell death than other examined agents. A potenet apoptotic influence of Diclofenac was also confirmed by data obtained from TUNEL assay. Dose-dependent inhibitory effects on Matrix metalloproteinases (MMPs) was seen in higher degree in Diclofenac compared with other examined NSAID(Piroxicam) and a synthetic glucocorticoid (Dexamethasone). Conclusion: based on our data, the induction of apoptosis together with MMPs inhibition could be indicative of cancer treatment, thus Diclofenac might be considered as a chemopreventative agent in cancer.

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