Ali J, Mazari N, Hameed A, Chandia Gm, Mohsin S.
Prevalence Of Monoclonal Gammopathy Of Undetermined Significance In A Tertiary Care Hospital Of Lahore.
Biomedica Jan ;34(1):15-9.

Background and Objectives: Monoclonal gammopathy of undetermined significance (MGUS) is the most prevalent among the group of disorders called Plasma cell dyscrasias. Differentiating MGUS from other monoclonal gammopathies is important because a conservative management plan is required for individuals with MGUS. Limited research has been done on the epidemiology of MGUS in Pakistan. This study was aimed at estimating the prevalence of MGUS in Pakistani adults. Methods: A random sample of 383 subjects aged 50 years or older visiting OPD of a tertiary care hospital in Lahore, Pakistan was taken. Individuals having any clinical manifestation of multiple myeloma or related disorders were excluded from the study. Complete blood count (CBC), erythrocyte sedimentation rate (ESR) and Serum Protein Electrophoresis were performed. Results: The crude prevalence of MGUS was found to be 8.6%, which is higher than observed in previous studies. Multivariate analysis of study subjects showed that old age and elevated ESR were the most important risk factors for MGUS. This is the first research to find out the prevalence of MGUS in the Pakistani adults. Conclusion: In this study MGUS is seen to be more prevalent in our patients particularly in older age group.

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