Aisha Akbar, Ghazala Mudassir, Mariam Abid, Hania Naveed, Mahwish Majeed.
Correlation of Molecular Subtypes with Clinico-pathological Parameters in Breast Carcinoma.
J Rawal Med Uni Jan ;22(4):318-21.

Background: To determine the correlation between clinic-pathological parameters, like age of the patient, size of the tumour, histologic type and grade with molecular subtype. Methods : This observational study included cases of breast cancer (n=50) . Histological grade was assessed according to Nottingham modification of Bloom-Richardson system. Representative sections with tumour and the adjacent normal tissue ( internal control) were processed for ER, PR and HER-2neu immune-histochemical staining. The scoring of ER and PR was carried out using Allred scoring system. Molecular subtypes were defined as, triple negative/basal type (HER 2 -,ER- and PR-), hormone receptor (HR) +,HER2-/luminal A (HER2-, ER+ and PR+ or -), HR+,HER2+/luminal B (HER2 +,ER+ and PR+ or-), HR-,HER2+/HER2 enriched (HER2+, ER- and PR -). Results: Majority (96%) were infiltrating ductal carcinoma, one was invasive lobular carcinoma and one was colloid carcinoma. Three cases (6%) grade 1 carcinoma were recorded of which one case (2%) each was of luminal A, luminal B and HER2 enriched type. There were 23 (46%) grade 2 cases of which 8(16%) were luminal A, 7(14%) of luminal B, 7(14%) of HER2 enriched and one (2%) was basal like. There were 24(48%) grade 3 cases of which 6(12%) were luminal A, 9(18%) of luminal B, 6(12%) were HER2 enriched and 4(8%) were basal like. Conclusion: Along with other variables, molecular subtype is important in predicating prognosis of carcinoma breast. Luminal A cancers are more common in older age, while Luminal B are common in younger age group.

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