Zahid A, Abidi T S.
Effect of chloroquine on liver weight of developing albino rats.
J Pak Med Assoc Jan ;53(1):21-3.

OBJECTIVE: To see the effect of chloroquine on liver weight of developing albino rats. METHODS: Twenty four pregnant female albino rats were used and divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700 mg/kg body weight in first second and third weeks of pregnancy. RESULTS: Chloroquine caused decrease in liver weight in offsprings specially in those which were exposed to drug during second and third week of pregnancy. CONCLUSION: The use of chloroquine should be avoided during pregnancy.

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