Ahmad Shamim, Waheed-ul Hamid, Muhammad Ilyas, Samina Qadir, Ushna Ahmad.
Effects on Alkaline Phosphatase Level in Crevicular Fluid Produced by Rapid Palatal Expansion with Hyrax Expander.
J Pak Dent Assoc Jan ;26(2):72-8.

Introduction: Rapid maxillary expansion (RME) is a dramatic and preferred procedure having a history of over 100 years. When a transverse maxillary Arch is diagnosed it is corrected by doing RME. Although several studies have been done in last four decades on gingival crevicular fluid, no data have been reported on the repeatability of gingival crevicular fluid collection and then following its quantification procedure. The objectives of this study were to examine the changes in alkaline phosphatase (ALP) activities in gingival crevicular fluid (GCF) during rapid palatal expansion and in retention period by hyrax, and to explore the relationship between these changes and periodontal tissue remodeling.Methodology: Seventeen patients with age between 9-14 years were selected according to inclusion and exclusion criteria. Periodontal parameters, including probing depth, were recorded at 3 months after RME. Furthermore, the GCF ALP activity was measured at the buccal and palatal sites.Results: Periodontal parameters were generally similar between the Testing and Control sites during the study, with the exception that probing depth underwent a slight increase at the Testing sites. It was observed that at baseline, the GCF ALP activity was similar between the buccal and Control sites; however, at 3 months of retention period a significantly greater enzymatic activity was seen at the Testing sites. Conclusion: The results of our study concluded that in the retention phase of RME, there is reported increase in GCF ALP activity even at the end of 3 months of retention period with no clinically significant tissue inflammation. This increase in GCF ALP activity demands a longer period of retention phase may be up to 6 months of duration. KEYWORDS: Gingival Crevicular Fluid, Alkaline Phosphatase, Rapid Palatal Expansion, Bone Remodeling, Hyrax Expander.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com