Hameed Tajammal Khan, Cheema K K.
Rifampicin induced Proteinuria.
Pak Postgrad Med J Jan ;13(4):137-8.

Tuberculosis is a highly prevalent disease with increasing mortality.1 Its chronic course leads to gradual deterioration of virtually all systems of the body as it spares none. Anti tuberculous medicines are one of the most commonly prescribed groups of drugs. Generally safe, they are still associated with frequent adverse effects. These usually appear in the form of raised liver enzymes or abnormal blood counts. Though no definite data exists regarding the true nature of renal involvement with anti tuberculous drugs, the association has long been known.2,3,5 The actual incidence and prevalence rates are still to be known. Majority of patients with renal symptoms however go unrecognized due to unawareness on part of the treating physicians. Recently the true impact of the problem has been highlighted with collective studies in patients from most prevalent parts of the world. Anti tuberculous therapy in general and Rifamicin in particular has been implicated in a wide range of renal affections from benign proteinuria to life threatening acute renal failure. As Pakistan has one of the highest numbers of reported cases of tuberculosis it is important for the clinicians to recognized renal symptoms early in the course of treatment.

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