Al Arfaj A S.
Serum Uric Acid and Radiographic Osteoarthritis.
J Pak Med Assoc Jan ;53(5):187-9.

Objectives: To investigate the association between serum uric acid levels and radiographic osteoarthritis (OA). Methods: Two hundred and forty one patients (135 males, 106 females) were enrolled in this study, covering fourteen primary care clinics. Their serum uric acid results and radiograph of knees and hands were obtained prospectively. The presence of radiographic osteoarthritis of the knee and generalised osteoarthritis were analysed in relation to serum uric acid values. Results: Their mean age was 48.9 t 15.3 (female 46.1 ± 13.9, males 51.3 t 16.1). Knee OA was present in 120 patients (48.8%), 57 (23.6%) females and 63 (26.1%) males. Generalized OA was seen in 54 (22.4%) patients, 20 (8.2%) females and 34 (14.1%) males. After adjusting for age, sex, BMI, serum cholesterol and triglycerides, there was an association between knee OA, generalized OA and the highest tertile of serum uric acid [adjusted odds ratio (OR) 2.03, 95% CI, 1.58-2.71 and 1.81, 95% CI, 1.33-2.57 respectively). Conclusion: It is concluded that knee and generalized OA are associated with hyperuricemia (JPMA 53:187;2003).

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