Mohammad Shaphiullah, Sitesh Chandra Bachar, Joydeb Kumar Kundu, Farida Begum, Aftab Uddin, Suvash Chandra Roy, Mohammad Tareq Hossain Khan.
Antidiarrheal activity of the methanol extract of Ludwigia Hyssopifolia Linn.
Pak J Pharm Sci Jan ;16(1):7-12.

Dried whole plant parts of Ludwigia hyssopifolia were subjected to successive cold extraction with n-hexane, ethylacetate and methanol. The methanol extract (LHM), obtained as 1 % yield, showed significant antidiarrheal property by reducing diarrheal episodes in castor oil and serotonin induced diarrhea in laboratory mice at a dose of higher than 100mg/kg body weight as compared to standard drug loperamide given at a dose of 66.67 ug/kg body weight. The percent reduction in diarrheal episode by 56.32 and 89.66 after castor oil challenge and 59.09 and 86.36 in serotonin induced diarrhea was observed at doses of 200mg/kg and 400mg/kg body weight of the extract respectively. The extract LHM was also found to reduce the gastrointestinal motility by 53.8% at a dose of t00mg/kg body weight as compared to control, while no remarkable inhibition of gastrointestinal motility was seen at a dose of 50mg/kg body weight of the extract.

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