Shamsi T, Huma Z, Baig M I.
Fibrin Glue for the control of external bleeding in Hemophilia: a cost effective and novel approach.
J Pak Med Assoc Jan ;53(7):310-12.

Objectives: To see the efficacy of fibrin glue for external bleeding in haemophilia patients to maintain haemostasis. Study Design: During last 5 years 68 bleeding episodes were treated in 32 haemophilia patients. Setting: Haemophilia Care Unit, Ziauddin Medical University Karachi and Bismillah Taqee Blood Diseases Centre, Karachi. Patients and Method: Sixty eight episodes occurred in 32 patients who had variable degree of severity of disease and presented with minor external post-traumatic bleed. There were 66 males and 2 females whose ages ranged from 6 months to 28 years. Fibrin glue was constituted by mixing fibrinogen (cryoprecipitate) and a 1:50 dilution of commercially available Thrombin calcium (Stago, France). Twenty ml of thawed cryoprecipitate was filled in one syringe while 10 ml diluted thrombin in another syringe. This was poured on the wound. Results: Out of 68 patients, who received fibrin glue treatment, 41 patients responded well with fibrin glue alone while 23 patients required single dose of factor concentrate. Four patients received multiple dose of factor VIII concentrate along with FFP. Conclusion: Fibrin glue can be used to control the bleeding in haemophilia patients. It reduces the use of factor concentrate (JPMA 53:310;2003).

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