Nayyara Tahir, Rukhsana Kausar.
Prevention of Fall in Red Blood Cell Count by Carica Papaya Leaf Juice in Carbolatin Induced Aneamia in Mice.
Esculapio J Services Inst Med Sci Jan ;13(4):174-8.

Objectives: To determine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced anaemia in mice. Methods: A total of 55 Swiss albino mice were randomly divided into five groups (C,M10, M5, F10 and F5). Anaemia was induced in all groups by a single intraperitoneal injection of carboplatin. Male papaya leaf juice was given to prevent of anaemia to groups M10 and M5 and female papaya leaf juice was given to F10 and F5. On days O, 7, 14 and 21 blood samples were collected by cardiac puncture for red blood cell count. Significance of different was calculated by one way ANOVA. Results: After carboplatin injection, RBC count decreased. Papaya leaf juice prevented fall in RBC count throughout the study period with p-value < 0.001. Difference between male and female papaya leaf juice was not significant while higher dose (10 ml/kg) produced significantly higher responses as compared to low dose (5 ml/kg). Conclusion: Papaya leaf juice prevents anaemia induced by carboplatin in a dose dependent manner. There is no difference between male and female plants in this respect.

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