Shazia Nazar.
Genetic Variability of Omentin-1 Gene in Apparently Healthy Population.
Ann Jinnah Sindh Med Uni Jan ;5(1):10-4.

Objective: Omentin-1 is a recently identified adipokine, highly expressed in visceral omental tissue with anti-inflammatory, antiatherogenic, and antidiabetic properties. Several studies have reported the association of Omentin-1 gene +326 A/T variant with different diseases such as type 2 diabetes, coronary artery disease, rheumatoid arthritis, psoriasis, and breast cancer in different populations. Therefore, the present study was designed to assess the frequency of omentin-1 gene +326 A/T variant in the apparently healthy Pakistani population. Methodology: This cross-sectional analytical study was conducted at two tertiary care hospitals of Karachi. Participants were recruited from January 2016 to August 2016. The study group comprised of 110 apparently healthy individuals including doctors, nurses, lab technicians, and patients attendants. Omentin 1 gene +326 A/T variant was determined by polymerase chain reacton-restricted fragment length polymorphism method. Results: In this study, the wild type genotype (AA) was observed to be 53.6%, mutant genotype (TT) was found to be 6.4%, while mutant genotypes (AT) was found in 40 %. However, the frequency of (AT) mutant genotype was found in 75% males. Conclusion: The prevalence of AT genotype in 75% of apparently healthy males is a significant finding of the current study. This data may help in the evaluation of population-based risk factors for a number of diseases asso

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