Amir Taimur Khan, Tahmeedullah, Obaidullah.
Treatment of necrotizing fasciitis with quinolones.
J Coll Physicians Surg Pak Jan ;13(11):649-52.

Objective: To evaluate the effect of high dose quinolones therapy in patients with necrotizing fasciitis. Design: descriptive analytical study. Place and Duration of Study: the department of Plastic and reconstructive surgery, Hayatabad Medical complex, Peshawar, from January 2001 to March 2002. Subjects and Methods: Twenty consecutive patients, diagnosed with necrotizing fasciitis, were treated with intravenous quinolones (400 mg 8 hourly). The response was evaluated in terms of subsidence of fever and C-reactive proteins levels. Results: Majority of the patients was male (60%). Lower limb involvement was most commonly involved (70%). The most common initiating cause was injection abscess (45%). Majority of the cultures showed polymicrobial infection (90%). The most common isolate was streptococcus pyogenes (65%). Majority of the patients showed excellent response with intravenous quinolones (Ciprofloxacin) in high doses in 24-48 hours. Only two patients (10%) failed to respond to therapy due to severe infection and delay in seeking treatment. Conclusion: Intravenous quinolones (Ciprofloxacin) in high doses are effective in controlling necrotizing soft tissue infections.

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