Jalaluddin AJ Khan.
Vitamin D status and serum level of some elements in Children with Sickle Cell Disease in Jeddah, Saudi Arabia.
Pak J Med Sci Jan ;19(4):295-9.

Objective: To study the relationship of Vitamin D deficiency and some minerals metabolism in the children with sickle cell disease (SCD) in the city of Jeddah, western region of Saudi Arabia. Design: Measuring the concentration of serum 25(OH) Vitamin D, calcium, phosphorus and magnesium in children with SCD aged between newborn to 12 years old. Methods: A total of 51 children with sickle cell disease (both gender) included 28 males (54.9%) and 23 females (45.1%) aged between newborn and 12 years old and 70 healthy matching controls were admitted or visited sickle cell section in the Maternity and Children Hospital in the city of Jeddah. Fasting blood samples were collected and the serum was separated and stored at –30ºC until the time of analysis. Serum 25 (OH) Vitamin D was determined using a commercially available kit (VDBP,Gc globulin), calcium, phosphorus and magnesium were measured using a clinical autoanalyser. Results: The patients were divided into two groups according to the ages. Group-A included 21 patients (both gender) aged between newborn and 6 years, group-B included 30 patients (both gender) aged between 7-12 years. The results obtained showed that the serum concentrations of 25(OH) Vitamin D in both patients groups were significantly lower than the healthy matching controls (P<0.01 and P<0.001), respectively. The serum concentrations of calcium, phosphorus and magnesium in group-A patients had no significant differences, whereas in group-B, the concentration of Ca+2 was significantly lower in patients than the controls (P<0.05), no significant differences in P in both groups (P>0.05) and significantly higher in the serum magnesium of group-B (P<0.05). Conclusion: A significant relation between Vitamin D deficiency and children with sickle cell disease which is normal due to confined patients indoor. The serum calcium concentration had no affect in the early stage of ages but a significant lower appeared with increasing of ages. The serum magnesium concentration was higher in group-B which can be explained to the important role of Mg+2 in the nature of erythrocyte membrane in sickle cell patients.

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