Fatima G, Niazi S, Jaffer R.
Androgen Receptor as a Prognostic Marker in Adenocarcinoma Prostate.
Biomedica Jan ;35(1):28-36.

Background & Objective: Prostate cancer is the second most common malignant tumor found in males. Androgen Receptor plays an important role in the development of normal as well as malignant prostatic tissue. The objective of this study was to see frequency of Androgen receptor in different grades of Gleason`s scoring system of Prostatic carcinoma. Methodology: It was descriptive cross sectional study conducted in department of pathology, King Edward Medical University and Urology Department of Mayo Hospital, Lahore from 1st Jan, 2015 to 31st Dec, 2015. Data was collected using purposive non probability sampling technique from 60 cases of prostatic cancer diagnosed on histopathology. Histopathological Grading evaluation was performed using the Gleason scoring system. Data entry and analysis was done by using SPSS version 22. Results: The mean age out of a total number of 60 cases was 67.33 +- 8.806 year with minimum and maximum age of 45 and 85 years. According to histological grades, 7 (11.67%) cases had low grade, 5 (8.33%) cases had intermediate and 48 (80%) cases had high grade tumor. In this study Androgen receptor was detected in 59 (98.33%) and it was not detected in 1 (1.67%) of the cases. As in 1 (1.67%) case Androgen was not detected so its score was 0, in cases whom androgen was detected there were 5 (8.33%) had +1 score, 25 (41.67%) cases had +2 score and 29 (48.33%) had score as +3. Conclusion: AR is a diagnostically useful marker for prostate adenocarcinoma. Tumors with high grades have shown strong positive expression for AR. Also, Gleason score and AR expression have shown direct relationship with each other.

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