Ayisha Shakeel, Syed Imtiaz Ali, Sharjeel Sultan.
Comparison of Post-operative Endophthalmitis prophylaxis using Intracameral cefuroxime and moxifloxacin in rural Pakistan- a randomized controlled trial.
Isra Med J Jan ;12(1):3-6.

Objective: To compare the efficacy and safety of Intracameral Cefuroxime and Moxifloxacin in preventing postop endophthalmitis in rural areas. Study Design: A Randomized controlled trial Place and Duration: At Layton Rehmatullah Benevolent Trust (LRBT) Free Secondary Eye Hospital, Akora Khattak, from 1st January 2010 till 31st January 2011. Methodology: Patients undergoing cataract surgery were randomly distributed in three groups A, B and C. Group A underwent routine aseptic technique of phacoemulsification without Intracameral antibiotic injection of any kind. Group B after routine phacoemulsification received an additional Intracameral Cefuroxime injection in the dose of 1mg/0.1ml at the end of surgery while Group C after routine phacoemulsification received Intracameral Moxifloxacin 5%. Patients were followed for four weeks post operatively and frequency of Endophthalmitis was noted in the patients. Post-operative visual acuity and reaction in the anterior chamber was also noted. Results? A total of 908 patients were operated for cataract surgery during this period. The mean age of patients in all the groups was 60 years and 56% of the patients were males. The frequency of post op endophthalmitis was 1.2% in Group A, whereas the frequency was 0% in both Group B and C. There was trace to +1 cells in the anterior chamber on the first post op day in 84% of patients in the group A, 97% of patients in group B and 95% of patients in group C. However, there was no reaction one week post op in 95% of patients in group A, 98.8% of patients in group B and 97.8% of patients in group C. Initial results reflected that there were fewer cases (P <0.05) of post op endophthalmitis following Intracameral antibiotic injections. Conclusion: Intracameral use of cefuroxime and moxifloxacin is effective in controlling post-operative endophthalmitis in rural Pakistan with high frequency of cataract surgeries without untoward side effects.

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