Rukhsana Suhail Chughtai, Riffat M. Butt, Ashfaq Ahmad, Sajjad Hassan.
Beta Adrenergic Blocking Agents: Local Anaesthetic Activity, Comparison With Lignocaine.
Ann King Edward Med Uni Jan ;4(3):47-9.

The local anaesthetic activity of Propranolol has been well documented. In this study four Beta Blocking Agents have been tested to find out if these agents also have this property.Propranolol, Timolol, Atenolol end Labetalol were compared with the local anaesthesia produced by Lignocaine. The method employed was intro-dermal wheal injection, into the skin of the lower back of experimental rabbits. Propranolol and Labetalol produced significant local anaesthetic, whereas Timolol and Atenolol failed to achieve the same effect.

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