Khalida Ahtesham, Rozina Jaffer, Ambreen Anwar Imran, Munazza Hasan, Sarosh Majid Salaria.
Correlation of mAgNOR and pAgNOR with grade of invasive ductal carcinoma of breast.
J Sharif Med Dent Coll Jan ;1(1):18-21.

Objective: To compare the argyrophilic nucleolar organizer regions (AgNORs) pattern with the histological grade of invasive ductal carcinoma of breast. Methodology: In this cross sectional study, fifty cases of invasive ductal carcinoma of breast diagnosed on trucut biopsy, core biopsy, incision biopsy or excision biopsy were collected from Lahore General Hospital, Lahore. Hematoxylin & Eosin staining and AgNOR staining were done. Results: The mean age of the patients was 46.84 years. Maximum number of cases were in 40-49 years age group. The difference in mAgNOR in grade II and grade III tumors was statistically significant whereas the difference in pAgNOR was statistically insignificant. Conclusion: mAgNOR correlates well with histological grade and results are statistically significant. Key words: Argyrophilic Nucleolar Organizer Regions. Breast carcinoma. Modified Bloom and Richardson grade.

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