Masood Hameed Khan, Muhammad Masroor, Rana Qamar, Iftikhar Ahmed, Faisal Ozair.
A prospective study of the micro-organisms and their antibiotic resistance in acute exacerbation of COPD.
Pak J Chest Med Jan ;9(3):3-12.

This was a prospective descriptive study conducted over a period of 9 months in patients with Acute Exacerbation of COPD (AECB) with an idea to demonstrate the causative organism, their relative frequency and their resistance to antimicrobials. Fifty adult patients of both Sexes between ages 26-80 years fulfilled the criteria of acute bacterial exacerbation of chronic bronchitis were enrolled. These included 40 males (80%) and 10 females (20%). Fortyone patients had positive cultures. Streptococcus pneumonia was the commonest organism, found in 20/41 patients, followed by Moraxella catarrhalis in 7/41, H.influenzae in 6/41 staph.aureus in 5/41 and pseudomonas aeruginosa in 3/41 patients. Twenty four to twenty seven percent isolates of streptococcus pneumonae were resistant to commonly used antibiotics like penicillins, Erythromycin and Co-trimoxazole. Thirty two percent H.influenzae were resistant to these antibiotics. Therefore antibiotic resistance evaluation is always recommended.

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