Muhammad Athar Abbasi, Ambreen Anwar, Aziz-ur Rehman, Sabahat Zahra Siddiqui, Kaniz Rubab, Syed Adnan Ali Shah, Muhammad Arif Lodhi, Farman Ali Khan, Muhammad Ashraf, Umber Alam.
Synthesis, enzyme inhibition and molecular docking studies of 1- Arylsulfonyl-4-phenylpiperazine derivatives.
Pak J Pharm Sci Jan ;30(5):1715-24.

Heterocyclic molecules have been frequently investigated to possess various biological activities during the last few decades. The present work elaborates the synthesis and enzymatic inhibition potentials of a series of sulfonamides. A series of 1-arylsulfonyl-4-Phenylpiperazine (3a-n) geared up by the reaction of 1-phenylpiperazine (1) and different (un)substituted alkyl/arylsulfonyl chlorides (2a-n), under defined pH control using water as a reaction medium. The synthesized molecules were characterized by 1 H-NMR, 13C-NMR, IR and EI-MS spectral data. The enzyme inhibition study was carried on ?-glucosidase, lipoxygenase (LOX), acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) enzymes supported by docking simulation studies and the IC50 values rendered a few of the synthesized molecules as moderate inhibitors of these enzymes where, the compound 3e exhibited comparatively better potency against ?-glucosidase enzyme. The synthesized compounds showed weak or no inhibition against LOX, AChE and BChE enzymes.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com