Sibghatullah Sangi, Kausar Aamir, Jamal Ara, Saba Tasneem, Arshad Qureshi, Nighat Kafil, Shah Murad Mastoi.
Effects of promethazine on uterine contractions, produced by prostaglandin E2 (PGE2).
J Surg Pak Jan ;7(4):8-11.

To observe the extent to which promethazine effect uterine contractions produced by prostaglandin E2 (PGE2) and to see the presence of peripheral benzodiazepine receptors in rat uterus. A study was conducted to see the interaction between promethazine and PGE2 in experimental rat uterus in vitro as both these drugs are being used simultaneously in eclampsia. It was for the first time that tocolytic effects of promethazine were being studied. Results of this study show that promethazine is significantly tocolytic invitro.

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