Iffikhar Ahmed, Muhammad Shakeel Ahmed, Riffat Khurshid, Abdul Khaliq Naveed.
Effect of CAD duration on plasma lipids and lipoproteins concentration..
Pak J Pathol Jan ;11(4):4-6.

Present study evaluated a new factor i.e. effect of coronary artery disease (CAD) duration on plasma lipids and lipoproteins concentration. 105 patients of atherosclerotic CAD were divided as: group-A (n=59) having CAD duration 1 year, group-B (n=25) 2 years and group-C (n=21) having CAD duration 3 years. In group-A, 79% patients had positive history of vegetable oil use, group-B, 68% and in group-C 61% patients have positive history of vegetable oil use in their diet after onset of CAD symptomatology. Results showed that total cholesterol (TC), LDL and LDL-C which were significantly raised in group-A and B, become non-significantly raised levels in group-C when each group compared with control subjects (n=35) while except significantly decreased levels (p<0.02) of HDL2-C. In group-B, all other parameters (TC, triglycerides, LDL, LDL-C, VLDL-C, THDL-C and HDL-C) showed non-significant difference when compared with group-A. Non-significant difference in levels also seen in group-C when compared with group-A. Study concluded that after 3 years of CAD duration TC, LDL and LDL-C levels were decreased. However, this effect may be depended upon vegetable oil use. While effect of CAD duration on HDL-C levels remained controversial.

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