Aliya Zahid, Taquayya S Abidi.
Morphological and histological evaluation of developing kidney in Rats exposed to Chloroquine.
Proceeding Shaikh Zayed Postgrad Med Inst Jan ;16(1):5-10.

A study was carried out to see the effects of chloroquine on kidneys of developing albino rats. In this study, 24 pregnant female albino rats were divided in 4 groups. They were kept in Animal House of Post Graduate Medical Institute, Lahore. Total gestational period in rats ranges from 20-22 days, which in this study was divided into three trimesters, each of seven days. Using oral dose of chloroquine 700mg/kg body weight in first, second and third trimesters of pregnancy, it was found that chloroquine induced nephrotoxicity in newborn rats which were exposed to drug during their intrauterine life. There was statistically significant decrease in kidney weight of offsprings in treated groups. Histological sections of kidney showed that there were degenerative changes in proximal and distal convoluted tubular cells. Some areas in cortex showed glomerular congestion. Demarcation of cortex and medulla was lost at some places. Subcapsular and parenchymal haemorrhages were also seen in few regions. All these changes were more marked in those animals which were exposed to drug during last trimester of gestation. It was concluded from the present study that chloroquine should be avoided during pregnany, especially during last trimester.

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