Iqbal Bano, Farah Haroon, Kholoud Bashir Malik, Attia Bari, Ahsan Waheed Rathore.
Efficacy of Nasal Continuous Positive Airway Pressure by Bubble CPAP in Neonates with Respiratory Distress Syndrome.
Pak Paed J Jan ;45(4):384-8.

Objective: Efficacy of Bubble CPAP in neonates with respiratory distress syndrome as the primary mode of respiratory support. Study Design: Descriptive case series. Place and Duration of Study: Neonatology Department of Children Hospital and Children`s Hospital & University of Child Health Science Lahore duration of study was 6 months, from 06-04-2017 to 05-10-2017. Material and Methods: Ninety five premature newborns (<=34 weeks gestation) admitted to the NICU were included having respiratory distress and chest X-ray suggestive of RDS. Bubble CPAP was used for ventilation of these neonates. Outcome variable was frequency of successful treatment assessed after 24 hours. Results: The mean gestational age of patients in our study was 31.24 +- 1.99 weeks and the mean age of the patients was 70.24 +- 26.72 hours. There were 58 (61%) male and 37 (39%) female patients with a male to female ratio of 1.6:1. Mean birth weight was 2.32+-0.37 Kg. Mean respiratory rate at admission was 71.21+-5.87 breaths/min while the mean oxygen saturation was 78.19+-5.34%. After 24 hours of bubble CPAP, there was significant improvement in the mean respiratory rate (56.57 +- 4.58 vs. 71.21 +- 5.87 breaths/min; p=<0.001), mean oxygen saturation (89.86+-2.31 vs. 78.19 +- 5.34%; p=<0.001) and frequency of chest in-drawing (14.7% vs. 70.5%; p=<0.001). Successful treatment (efficacy) was found to be 80 (84.2%). Conclusion: Bubble CPAP may be considered as a first line respiratory support in preterm and very preterm babies with RDS. Its routine use for such neonates in future practice before opting invasive ventilation reduces the need of mechanical ventilation.

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