Aamer Naseer, Saadia Sharif, Sehrish Khan, Mahnoor Aamer.
Comparison between Efficacy of Levetiracetam and Sodium Valproate in Pediatric patients with Status Epitepticus.
Pak Paed J Jan ;46(1):25-30.

Objective: To compare the efficacy of levetiracetam (LEV) versus sodium valproate (VPA) in pediatric patients with status epilepticus (SE) Study Design: Randomized controlled trial Place and Duration of Study: Study was conducted in the department of Pediatrics, Jinnah Hospital, Lahore. Its duration was six months from January 2021 to June 2021. Material and Methods: Total of 144 patients who fulfilled the inclusion criterion were divided into two groups. In group A, sodium Valproate (VPA) while in group B, Levetiracetum (LEV) was given intravenously. The efficacy was noted after 24 hours. All the data were entered and processed by using SPSSv 25.0. Data were stratified for age, gender and weight to deal with effect modifiers. Post-stratification, Chi-square test was used. A p-value <= 0.05 was considered significant. Results: 144 patients were divided in two groups A and B. In group A (VPA), 51 (70.8) were males and 21 (29%) females, while in group B, there were 53 (73.6%) males and 19 (26.4%) females. The mean age of patients in group A was 8.3 + 3.6 year and in group B was 8.1 + 3.7 year. According to efficacy, 34 (47.2%) has efficacy with (VPA) and 49 (68.1%) with LEV with a p value 0.011 which in statistically significant. Conclusion: Levetiracetam can be used as a safe and effective antiepileptic in the treatment of children suffering from status epilepticus.

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