Zahid Niaz, Salman Bokhari, M. Imran Anwar, M. Tariq Latif.
Prevalence of Helicobacter Pylori and its Implications in Perforated Duodenal Ulcer.
Biomedica Jan ;17:6-10.

Although Helicobacter pylori is now widely accepted as a cause of peptic ulcer disease, its role in peptic ulcer complications is still under trial and study worldwide. The aim of this study was to ascertain the prevalence of Helicobacter pylori in cases of duodenal ulcer perforation and the correlation with commonly accepted predisposing factors. Also evaluated was, the role of simple closure of perforation with H. pylori eradication as an alternative to immediate acid reduction surgery in these cases. Thirty consecutive cases of perforated duodenal ulcer undergoing simple closure or omentoplasty alone were serologically tested for the presence of IgG antibody against 11. Pylori. All received post-operative antimicrobial treatment and were followed up periodically for twelve months. A high prevalence rate of 76.67% of 11. pylori was observed with a M/F ratio of 6.7:1. Infection rates were maximum in the elderly and those belonging to poor social class. All smokers carried H. pylori but NSAIDs appeared as an independent causative factor. None of the patients reported any symptomatic recurrence until 12 months. The results coincide with other international data and prove the causative role of H. pylori in perforated duodenal ulcer and the therapeutic significance of H. pylori eradication therapy.

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