Ahmad Saleem, Noreen Akmal, Nuzhat Malik, Amna Akmal, Arif Malik, Mukhtar Ahmad.
Extrapolative factors and oxidative profile in young pregnant females suffering from preeclampsia.
J Allama Iqbal Med Coll Jan ;19(4):920-6.

Background: Preeclampsia is a life threatening complication of pregnancy that starts at 20th week of gestation and is typically related to widespread vascular endothelial malfunction and vasospasm. .Clinically it is defined as raised blood pressure (HTN), either equal to or higher than 140/90 mmHg and proteinuria (albumins in urine, 300mg/24H or more). Or a proteinuria of 1+ or more on repeated measures on dipstick method with a systolic blood pressure of more than 140 mmHg or a diastolic blood pressure of more than 90 mmHg on repeated readings, after 20th week of gestation (Hubel, 1999). Hereditary predisposition is also an important factor. Its prevalence in different relations is, Sisters 37%, Daughter 26%, and Grand daughters 16%. Methods: Pregnant females diagnosed as having preeclamsia at the Jinnah hospital Lahore and Sir Ganga Ram Hospital, Lahore were selected. Total of one hundred (100) females were taken for present study, fifty (50) as control and remaining fifty (50) were included in the patient group. Informed consent was obtained before being included in this study. Results: Highly significant (p=0.0l4) difference of malondialdehyde level was observed between women suffering from preeclampsia and normal subjects (5.26±01.23 Vs. 0.93±0.065 umol/L). Level of antioxidants such as SOD, GSH, CAT and GPx was decreased (0.l09±0.016 U/ml, 4.26±l.44 umol/L, 2.99±0.923 U/L and4.26±l.44 umol/L respectively) in preeclatnpsia patients as compared to controls (0.66±0.023 U/l, 9.66±2.55 umol/L,6.35±1.88 U/Land 8.89±3.26 umol/Lrespectively). Conclusion: The study concludes that increase in oxidative stress and pro-inflammatory cytokines are not only involved in endothelial cell dysfunction but can also be considered as one of the potential source for preeclampsia. Enhanced inflammatory response could be seen due to the increased pro-inflammatory cytokines, neutrophil activation, leukocyte activation and acute phase proteins in preeclampsia Out of all cytokines, IL-6 and TNF alpha are considered to play primary role in the immune activation.

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