Qurat-ul Ain, Mehwish Gilani, Naveed Asif, Ammad Akram, Khurshid Muhammad Uttra, Amer Siddiq.
Evaluation of Reference Interval of Serum Uric Acid Level During Pregnancy in Tertiary Care Hospital of Rawalpindi.
Pak Armed Forces Med J Jan ;72(2):471-74.

Objective: To determine the reference interval of uric acid in uncomplicated pregnancies. Study Design: Cross-sectional study. Place and Duration of Study: Pathology Department, Armed Forces Institute of Pathology,, Rawalpindi, Pakistan. Methodology: Data was collected from 807 pregnant females after informed consent. Healthy females of first and secondtrimester gestational amenorrhea with no previous significant surgical, medical and gynecological/obstetric history were included. In contrast, patients on drugs like anti-epileptics, anti-hypertensives, steroids, and poor obstetric history were excluded. Information regarding dietary, medical and family history and the use of tobacco, beverages, and current physical activity was collected using a standard questionnaire. Reference Interval was computed by using the 3rd and 97th percentile systems. Results: Mean age of study participants in the first trimester of pregnancy was 22.37 ± 2.54 years, while in the second trimester was 27.14 ± 3.62 years. Data was segregated into three age groups: 18-29 years (186, 23%), 30-35 years (452, 56%) and 36-43 years (169, 21%). Uric acid levels observed in the first and second trimesters were 95.8-260.14 umol/l and 96-268 umol/ respectively. Conclusion: Serum Uric Acid levels differed in normal pregnancy compared to the non-pregnant state. Moreover, this study also provides optimal reference intervals of uric acid levels for pregnancy's first and second trimesters.

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